Nowadays, all the really good discoveries require PhD's and complex laboratories burrowed inside mountains in Switzerland. There's no chance that some nobody like me is going to finally crack chaos theory or whatever it is that super-geniuses work on. It's too late to be immortalized for finding the double-helix pattern of DNA, or for figuring out gravity, or knowing that water boils at 212*. Basically, anything that could be discovered by thinking really hard, it's been done, and now you have to know math and science and own a microscope to do ground-breaking work.
Maybe I should buy a microscope.